The TERBINAFINE HYDROCHLORIDE LOADED FENUGREEK GUM-BASED PH RESPONSIVE POLYMERIC CARRIERS

Abstract

Main objective of this study was to prepare co-polymeric pH responsive drug delivery system that can provide drug release in a controlled manner. Hydrogel network was developed by using free radical polymerization. Crosslinking was done by using N-N Methylene bisacrylamide (MBA) as a crosslinker and Methacrylic Acid (MAA) as a monomer. Developed network was evaluated for FTIR, DSC, TGA, PXRD, EDS, SEM, mechanical strength, sol-gel fraction and toxicity studies. For investigation of swelling and release behavior of these networks, studies were performed at pH 1.2 and pH 7.4. Drug release mechanism was evaluated by applying various release kinetic models. Stability of the Terbinafine Hydrochloride within developed network was confirmed through DSC and TGA findings. Formation of new complex was evident from FT-IR studies. All the formulations have shown acceptable gel ability. Terbinafine Hydrochloride loading within the carrier system was also confirmed through energy disperse spectroscopy. Beta-cyclodextrin (β-CD) assisted Fenugreek based hydrogels had shown promising results in terms of swelling and release. Developed network can also utilize for other therapeutic drugs having short half-life, poor bioavailability and extensive first pass issues.