Prevalence of chlamydia and levels of seminal antisperm antibody and oxidative stress markers of infertile men in Calabar, Southern Nigeria
Abstract
Background: Male infertility occurs globally and has a multifactorial aetiology. This study assessed prevalence of chlamydia and levels of seminal antisperm antibody (ASA), total antioxidant capacity (TAC), catalase and vitamin C of infertile men in Calabar, Southern Nigeria.
Basic procedures: This was a case-control study involving 35 oligospermic, 30 azoospermic men and 30 normospermic fertile men. Seminal chlamydial IgG antibody and ASA were done by Enzyme-linked immunosorbent assay, TAC, Vitamin C and catalase by colorimetry and semen analysis by WHO method. Statistical analysis was done using SPSS version 18.0 and data obtained was analyzed by the ANOVA, LSD Post hoc analysis, Pearson’s correlation and the level of significance was set at P < 0.05
Main findings: The oligospermic and azoospermic men had significantly lower (p = 0.0001) sperm count, sperm concentration, % sperm motility, catalase, TAC and significantly higher (p = 0.002) ASA than controls. Only the oligospermic men had significantly lower (p = 0.017) Vitamin C levels than the controls. They also had significantly higher catalase (p = 0.003) compared to the azoospermic men. None were positive for ASA and 4.4% of the infertile men were positive for chlamydia IgG antibody. Vitamin C correlated significantly and negatively with ASA (r= -0.388, p =0.009).
Principal conclusions: The prevalence of chlamydia and ASA of infertile men in this study was 4.4% and 0% respectively, seminal TAC, catalase and Vitamin C were lower and ASA higher in infertile men than fertile men.
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